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Studying the Forest, Not the Trees: Dendritic Morphology in Populations of Neurons.
Tom Verhovshek, B.S., Dale Sengelaub, Ph.D., October, 1999.,
Vol. 51
"For several years we have been studying the development and adult plasticity of dendritic morphology in small populations of spinal moto-neurons in rats."
This article contains a great overview of dendritic morphology.
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Intracellular Recording and Staining in the Acute In Vivo Rat using Sharp Electrodes.
Brian H. Bland, Ph.D., Jan Konopacki, Ph.D., September, 2000 .,
Vol. 52
"For a number of years now we have been studying the discharge properties of cells in the hippocampal formation (HPC) and related structures..."
This article describes the methodology for intracellular recording and staining using sharp electrodes in the acute in vivo rat.



A Central Noradrenergic Mechanism Responsible for Modulation of the Arterial Baroreceptor Reflex in Cats.
V.A. Tsyrlin, Ph.D., Yu. I. Shcherbin, Ph.D., May, 2001., Vol. 53
"It has been shown that in anaesthetized and conscious animals norepinephrine administrated intravenously for a long time produces a sustained inhibition of the renal nerve sympathetic activity..."
This study is to find a mechanism responsible for augmentation of the arterial baroreflex following intravenous infusion of norepinephrine.
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A Novel Technique for Multiple Injections into the Mammalian Optic Nerve.
Brian H. Hallas, Ph.D., Michael R. Wells, Ph.D., July 2001., Vol. 54
"As opposed to many areas of the CNS, the optic nerve may offer a relatively accessible number of CNS axons in a constrained space..."
This article describes the intention of these manipulations is to alter the cellular composition of CNS tracts and provide an appropriate microenvironment for axonal growth.



Long-Term Effects of Prenatal Stress on Acute and Tonic Pain in Male Rats.
I.P. Butkevich, Ph.D., September, 2001., Vol. 55
"Published data indicate an alteration of pain sensitivity to acute nociceptive irritants in offspring born to females subjected to stress during pregnancy..."
An investigation into the effects of prenatal stress on acute and tonic phases in the formalin test in 90-day-old male rats, the age generally used for the evaluation of long-term consequences of prenatal stress on an organism.

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Comparison of Sympathetic Reflex Activity Elicited by Single Shock to A-Type Afferent Somatic Fibres in Normotensive and Spontaneously Hypertensive Rats.
R.S. Khrustaleva, Ph.D., V.A. Tsyrlin, Ph. D., Yu. I Shcherbin, Ph.D.,
June, 2002., Vol. 56
"Recordings of multifiber nerve activity in spontaneously hypertensive rats (SHR) show increased central sympathetic discharge to various organs..."
This study compares the reflex responses in preganglionic sympathetic nerves evoked by somatic afferent stimulation in SHR and in WKY rats and to investigate the relative importance of the spinal cord compared to the medullary brain in mediating the somatosympathetic reflex in hypertensive rats.



Electrophysiological Assessment of Bilateral Spinal Activity in the Rat.
Allison Coleman, B.S., Dale Sengelaub, Ph.D., October, 2002 ., Vol. 57
"The spinal nucleus of the bulbocavernosus (SNB, also known as the dorsomedial nucleus or DM [Schroder, 1980]) of the rat contains motoneurons... "
An investigation of the role of gap junctions in bilateral SNB communication through electrophysiological assessment of motoneuron recruitment.
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On the Possible Mechanisms of Elevation of the Arterial Wall Extensibility in Response to Norepinephrine.
Alexander V. Syrenskii, Ph.D., Natalia S. Ruanova, Ilia V. Alexandrov, January, 2003., Vol. 58
"It is known that intravenous infusion of norepinephrine (NE) into anaesthetized animals is associated with an increase of arterial vascular..."
An investigation in the role of NO in regulation of arterial vascular responses to volumetric blood flow rate changes with intravenous NE infusion.



Single Preconditioning Stimulus Becomes Stronger When Combined with ACE Inhibitor Spirapril in the Rat Model of Myocardial Ischemia / Reperfusion.
Alexander V. Syrenskii, Ph.D., Dmitry L. Sonin, Michael M. Galagudza, Ph.D., October, 2003., Vol. 59
"A number of studies indicate that ACE inhibitors may be effective in reducing the extent of ischemic injury alone as well as ischemic injury..."
Studies the effects of angiotensin-converting enzyme (ACE) inhibitors on cardiac remodeling associated with congestive heart failure.

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J. David Kopf Memoriam.
Michael M. Patterson, Ph.D., Vol. 60
"In 1956, David was informed by his brother-inlaw that the scientists at the White Memorial Hospital in Los Angeles needed a stereotaxic device for..."
This is the story of the man who founded David Kopf Instruments. His work, his contributions to the neurosciences, his collections, his achievements and his love for life.

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